中文名 | 替硝唑 |
英文名 | tinidazole |
别名 | 替硝唑 磺甲硝咪唑 替硝唑原料粉 磺甲硝咪唑杂质 格列奇特(格列齐特) 替硝唑原料药生产厂商 1-[2-(乙磺酰基)乙基]-2-甲基-5-硝基咪唑 2-甲基-1-[2-(乙基磺酰基)乙基]-5-硝基-1H-咪唑 |
英文别名 | bioshik Dramion Nordialex Diamicron TINIDAZOLE tinidazole Tinidazole API TIMTEC-BB SBB006917 1-[2-(Ethylsulfonyl)ethyl]-2-Methyl-5-nitro- 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-imidazol 1-(2-(ethylsulfonyl)-ethyl)-2-methyl-5-nitroimidazole 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole |
CAS | 19387-91-8 |
EINECS | 243-014-4 |
化学式 | C8H13N3O4S |
分子量 | 247.27 |
InChI | InChI=1/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3 |
InChIKey | HJLSLZFTEKNLFI-UHFFFAOYSA-N |
密度 | 1.4338 (rough estimate) |
熔点 | 118-120?C |
沸点 | 528.4±30.0 °C(Predicted) |
闪点 | 273.4°C |
蒸汽压 | 1E-10mmHg at 25°C |
溶解度 | 几乎不溶于水,溶于丙酮和二氯甲烷,微溶于甲醇。 |
折射率 | 1.6320 (estimate) |
酸度系数 | 2.30±0.34(Predicted) |
存储条件 | Sealed in dry,Room Temperature |
稳定性 | 稳定。与强氧化剂不相容。 |
外观 | 整洁 |
颜色 | Off-White to Pale Yellow |
最大波长(λmax) | ['317nm(H2O)(lit.)'] |
Merck | 14,9447 |
BRN | 618182 |
物化性质 | 无色结晶。 |
MDL号 | MFCD00057217 |
体外研究 | Tinidazole在低MLC时杀死甲硝唑敏感株,但只能有效对抗12甲硝唑耐药株中的4株。 Tinidazole表现抗下列菌种的活性,致病性原生动物(例如,Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis),广泛的临床显著厌氧细菌(例如,Bacteroides fragilis, Clostridium difficile)和微需氧的幽门螺杆菌。在敏感原生动物和细菌细胞中,Tinidazole降低到细胞毒性中间体,它共价结合于DNA,从而导致细胞不可逆损伤。 Tinidazole抑制104 种T. vaginalis分离株,平均MLC为1014.9 μM。 Tinidazole影响滋养体对Giardia duodenalis的形态,依从性和可行性。 Tinidazole对40种Clostridium difficile,10种Prevotella bivia和11种Bacteroides fragilis临床分离株有活性,替硝唑和甲硝唑的平均MIC分别是: C. difficile,0.31 μg/mL和0.28 μg/mL;P. bivia,2.33 μg/mL与1.52 μg/mL;B. fragilis,0.5 μg/mL和0.71 μg/mL。 |
危险品标志 | Xn - 有害物品 |
风险术语 | R20/21/22 - 吸入、皮肤接触及吞食有害。 R40 - 少数报道有致癌后果。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
RTECS | NI6255000 |
海关编号 | 2933290000 |
上游原料 | 2-甲基-5-硝基咪唑 |
参考资料 展开查看 | 1. Sun, L., Chen, Y., Hou, C., Sun, X., Wang, Z., Li, S., ... & Chen, X. (2018). Neuroprotective effect of total glycosides from paeonies against neurotoxicity induced by strychnos alkaloids related to recovering the levels of neurotransmitters and neuroendoc 2. [IF=3.361] Linjia Sun et al."Neuroprotective effect of total glycosides from paeonies against neurotoxicity induced by strychnos alkaloids related to recovering the levels of neurotransmitters and neuroendocrine hormones in rat serum and brain."Rsc Adv. 2018 Aug;8(5 3. [IF=3.535] Hui Jiang et al."Determination of lipid–water partition coefficient of neutral and ionic drugs by liposome electrokinetic chromatography."Electrophoresis. 2021 Aug;42(14-15):1436-1449 4. [IF=2.044] Chen Guo-Ying et al."Immobilized Kallikrein Microreactor Based on Capillary Electrophoresis for Online Enzyme Kinetics Analysis and Inhibitor Screening."Chromatographia. 2021 Oct 11 5. [IF=3.935] Dongyuan Lu et al."A rapid and sensitive LC-MS/MS method for determination of the active component K6 in serum of patients with depression."J Pharmaceut Biomed. 2022 May;213:114691 6. [IF=3.935] Hui Jiang et al."Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability."J Pharmaceut Biomed. 2022 Feb;209:114513 |